The Study of Captopril Floating Matrix Tablets Using Different Polymers as Release Retarding Agent

The various approaches to increase the gastric residence of dosage forms are: effervescent single/multiple unit dosage forms, non-effervescent single/multiple unit dosage forms, high density dosage forms, expandable systems, swelling systems, unfolding systems, and adhesionmucoadhesive systems. The floating drug delivery systems of this class contains one or more gel forming swellable cellulose, polysaccharide. Captopril was used with various grades of HPMC in varying ratios to formulate the floating tablets. Lactose was used as a diluent in the preparation of the tablets. Sodium bicarbonate was incorporated into the tablets to aid buoyancy of the tablets. it was concluded that the formulation F1 is the best formulations as the extent of drug release was found to be around 85 %. This batch also showed immediate floatation and floatation duration of more than 8hr. The drug release model of this formulation complies with zero order kinetics. Based on the results we can certainly say that floating type gastro retentive drug delivery system holds a lot of potential for drug captopril.